A Familial Hemorrhagic Diathesis due to an Antithrombin

A familial hemorhagic diathesis due to an antithrombin.

IN A REVIEW published in 1955 Alexander’ stated that he knew of no well documented case of disturbed hemostasis in which excessive antithrombin activity had been the pthnary disorder. In 1955 Chevalier et al.2 reported briefly on three patients in whom purpura was accompanied by an increased capacity of serum to destroy thrombin during incubation at 37 C.; in at least one of these patients the ...

A hemorrhagic diathesis due to a qualitative platelet defect.

Familial thrombosis due to antithrombin 3 deficiency.

A large kindred from eastern Kentucky, with extensive history of recurrent venous thrombasis and pulmonary embolism, was studied. Low antithrombin III titers, ranging from 26% to 49% of normal values, were found in plasma of nine members in three consecutive generations; another five members, four of whom were not available for study, are suspected of having the biochemical defect. There was a ...

Severe thrombocytopenia and hemorrhagic diathesis due to brucellosis.

BACKGROUND We aimed to examine cases of brucellosis that presented with severe thrombocytopenia and hemorrhagic diathesis. METHODS A total of 10 brucellosis cases with severe thrombocytopenia were included in this case-series study. Patients' files were reviewed for their clinical and laboratory findings, as well as clinical outcomes and complications. Platelet counts of < 20,000/mm³ were dia...

A familial hemorrhagic diathesis in a Dutch family: an inherited deficiency of alpha 2-antiplasmin.

This study concerns a case of congenital homozygous deficiency in alpha 2-antiplasmin associated with a severe hemorrhagic diathesis. Heterozygous family members also show a mild bleeding tendency. The propositus is a 17-yr-old male born of white parents and showing a severe hemorrhagic diathesis characterized by spontaneous bleeding in the joints since his early childhood. He was originally su...